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US 12,509,552 B2Granted
Lipidated poly(amino acid) nanostructures
AssigneeThe Curators of the University of Missouri
InventorsJosiah Smith, Bret Ulery
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Abstract
The present disclosure is directed to novel lipidated poly(amino acid)s (LPAAs). The present disclosure is further related to processes for preparing such novel lipidated poly(amino acid)s (LPAAs) and for preparing novel lipidated poly(amino acid)s nanoparticles (LPAANPs). Additionally, the present disclosure relates to processes for utilizing lipidated poly(amino acid)s (LPAAs) that are biocompatible and capable of drug delivery.
Claims14
A lipidated poly(amino acid) consisting of lysine and valine,
- wherein at least a portion of the lipidated poly(amino acid) is in the form of a micelle or a nanoparticle,
- wherein the micelle or nanoparticle further comprises an entrapped component selected from the group consisting of a therapeutic component, a cancer destroying component, adjuvants, anti-inflammatory therapeutics, immunomodulatory drugs, vaccines, growth factors, a fluorophore-labeled peptide, a fluorophore-labeled peptide amphiphile, a protein, and combinations thereof, and
- wherein the lipidated poly(amino acid) comprises a lysine:valine ratio of about 2:1 or less.
A lipidated poly(amino acid) consisting of lysine and valine,
- wherein at least a portion of the lipidated poly(amino acid) is in the form of a micelle,
- wherein the micelle further comprises an entrapped component selected from the group consisting of a therapeutic component, a cancer destroying component, adjuvants, anti-inflammatory therapeutics, immunomodulatory drugs, vaccines, growth factors, a fluorophore-labeled peptide, a fluorophore-labeled peptide amphiphile, a protein, and combinations thereof, and
- wherein the lipidated poly(amino acid) comprises a lysine:valine ratio of about 2:1 or less.
Dependencies are inferred from the claim text.