High water content biomedical devices
AssigneeBausch + Lomb Ireland Limited
InventorsJames Anthony DiBella, Jr., Feng-Yang Shih, Mark R. Mis, Lindsey Cullen, Sandra Taft, Alok Kumar Awasthi
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Abstract
A biomedical device is disclosed. The biomedical device includes a polymerization product of a biomedical device-forming mixture containing (a) one or more grafted glycosaminoglycan polymers including a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and (b) one or more non-silicone biomedical device-forming monomers.
Claims20
A biomedical device comprising a polymerization product of a biomedical device-forming mixture comprising:
- (a) one or more grafted glycosaminoglycan polymers comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and
- (b) one or more non-silicone biomedical device-forming monomers;
- wherein the biomedical device has an equilibrium water content of at least about 80 wt. % and an oxygen permeability (Dk) of at least about 60.
A method for making a biomedical device comprising:
- (a) providing a biomedical device-forming mixture comprising (i) one or more grafted glycosaminoglycan polymers comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and (ii) one or more non-silicone biomedical device-forming monomers;
- (b) subjecting the mixture to polymerization conditions to provide a polymerized biomedical device;
- and
- (c) hydrating the polymerized biomedical device;
- wherein the biomedical device has an equilibrium water content of at least about 80 wt. % and an oxygen permeability (Dk) of at least about 60.
Dependencies are inferred from the claim text.