Back to results
US 12,509,498 B2Granted
Leucine zipper-based compositions and methods of use
AssigneeMemorial Sloan Kettering Cancer Center
InventorsScott E. James, Marcel R. M. Van Den Brink, Lorenz Jahn
Life of this patent
Estimating the term…
Abstract
The presently disclosed subject matter provides compositions and systems for cell-based immunotherapy. In certain non-limiting embodiments, the system comprises a membrane-bound polypeptide and at least one soluble polypeptide that is capable of dimerizing with the membrane-bound polypeptide.
Claims28
A system, comprising:
- a) a membrane-bound polypeptide comprising:
- i) a transmembrane domain,
- ii) an intracellular domain, and
- iii) an extracellular domain that comprises a first dimerization domain and a second dimerization domain that is capable of dimerizing with the first dimerization domain, and
- b) a soluble polypeptide comprising:
- i) a third dimerization domain that is capable of dimerizing with the first dimerization domain, and
- ii) an antigen binding domain that binds to an antigen,
- wherein each of the first dimerization domain, the second dimerization domain, and the third dimerization domain comprises a leucine zipper domain, the first dimerization domain and the second dimerization domain are an orthogonal pair, and the first dimerization domain and the third dimerization domain are an orthogonal pair.
5 more elements
Dependencies are inferred from the claim text.