US 12,509,469 B2 · Compositions and methods for the treatment of pain and dependence disorders

Abstract

Provided herein are (e.g., controlled release) compositions for the treatment of acute or chronic diseases or disorders. Described herein are processable opioid conjugates. Also described herein are compositions and methods for the treatment of central nervous system (CNS) diseases or disorders including chronic pain (e.g., cancer pain), acute pain, opioid addiction, alcohol addiction, alcohol dependence, opioid-induced constipation, and narcotic depression. Said compositions and methods comprise opioid agonists and/or opioid antagonists, which demonstrate CNS activity and/or other desirable activities. Injection of said compositions subcutaneously or intraspinally provides therapeutic benefit to individuals suffering from CNS diseases or disorders.

Claims13

Dependent claims

A compound having a structure represented by Formula (IID):

wherein:
R1 and R1′ are each independently unsaturated alkyl;
or R1 and R1′ are each independently cycloalkyl;
Ra and Ra′ are each independently H or —OH;
Ld is selected from the group consisting of —(CR2)y—, —O(CR2)yO—, —O(CR2)y—, —(CR2)yO—, and —O(CH2CH2O)y—, wherein y is 1-10 and each R is independently selected from the group consisting of H, hydroxyl, halogen, alkyl, or is taken together with another R to form an optionally substituted cycloalkyl;
and
X and X′ are each independently O or CH2, or
a pharmaceutically salt thereof.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/633,072Filed 6 Aug 2020 · us provisional application

Priority

7 Aug 2019

Published

US 2022/0274999 A11 Sep 2022

Granted

30 Dec 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 489/02
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4,…
A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/1617
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats
A61K 31/485
Quinolines; Isoquinolines: morphinan derivatives, e.g. morphine, codeine

Compositions and methods for the treatment of pain and dependence disorders

Life of this patent

Compositions and methods for the treatment of pain and dependence disorders

Life of this patent

Abstract

Claims13