Benzamide derivatives as cGAS-sting pathway agonists

A compound having formula (II):

• or a hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein:
• R1 is selected from a group consisting of hydrogen, halogen, optionally substituted C1-6 haloalkyl, optionally substituted C1-6 alkenyl, CO2R7, CONHR8, NHR9, NR9R10, OR10, cyano, N3, SO2R11, optionally substituted phenyl, optionally substituted heteroaryl, and N-containing monocyclic heterocycloalkyl;
• R3 is selected from a group consisting of hydrogen, halogen, optionally substituted C1-6 haloalkyl, optionally substituted C1-6 alkenyl, CO2R7, CONHR8, NHR9, NR9R10, OR10, cyano, N3, SO2R11, optionally substituted phenyl, optionally substituted heteroaryl, and N-containing monocyclic heterocycloalkyl;
• n is 1;
• R4 and R5 are taken together with the atom to which they are bound to form an optionally substituted cycloalkane ring having 5 ring atoms;
• R7 is selected from a group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C3-C7 cycloalkyl, and optionally substituted phenyl;
• R8 is selected from a group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C3-C7 cycloalkyl, and optionally substituted phenyl;
• R9 is selected from a group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C3-C7 cycloalkyl, and optionally substituted phenyl, optionally substituted heteroaryl, COR10, SO2R10;
• R10 is selected from a group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C3-C7 cycloalkyl, and optionally substituted phenyl, or two R10 units are taken together with the atoms to which they are bound to form a ring having 5-8 ring atoms, or R9 and R10 units are taken together with the atoms to which they are bound to form a ring having 5-8 ring atoms;
• R11 is selected from a group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C3-C7 cycloalkyl, and optionally substituted phenyl.