Optically resolved Trolox intermediate and method for producing same
AssigneePTC Therapeutics, Inc.
InventorsKiichi Kuroda, Kiyoto Sawamura, Shinjiro Tsuyumine
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for chiral resolution of Trolox. The present disclosure relates to a method for producing a solid salt of a compound of formula I, wherein an amide-based solvent is added to a sample, which contains a compound of formula I, while being assumed to contain a compound of formula II, in the presence of an optical resolution agent: Formula I: (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to R Trolox) Formula II: (S)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to S Trolox).
Claims56
A method of optically resolving a compound of formula I or a compound of formula II, comprising adding an amide-based solvent to a mixture of the compound of formula I and the compound of formula II:
- Formula I:
- (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (hereinafter R Trolox)
- Formula II:
- (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (hereinafter S Trolox).
Dependencies are inferred from the claim text.