1,4-dihydroquinazolinone compounds and uses thereof

A compound represented by Formula (II):

• or a salt thereof, wherein:
• n is 0, 1, 2, 3, or 4;
• each R1 is independently selected from:
• halogen, —NO2, —CN, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, and —S(O)2R10a;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —C(O)OR10d, —OC(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a;
• R2 is selected from:
• halogen, —NO2, —CN, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, and —S(O)2R10b;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —C(O)OR10b, —OC(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9b;
• or
• R2 together with R11 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9b′;
• R3 and R4 are each independently selected from:
• hydrogen, halogen, —OR10c, —SR10c, —N(R10c)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10c, —SR10c, —N(R10c)2, —NO2, and —CN;
• or
• R3 together with R4 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c;
• R5 and R6 are each independently selected from:
• hydrogen, halogen, —OR10d, —SR10d, —N(R10d)2, —NO2, and —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10d, —SR10d, —N(R10d)2, —NO2, and —CN;
• or
• R5 together with R6 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d;
• R7 is selected from:
• hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10e, —SR10e, —N(R10e)2, —NO2, and —CN;
• R8 is selected from:
• hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10f, —SR10f, —N(R10f)2, —NO2, and —CN;
• R11 is selected from:
• halogen, —NO2, —CN, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, and —S(O)2R10g;
• and
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —C(O)OR10g, —OC(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —S(O)R10g, —S(O)2R10g, —NO2, ═S, ═N(R10g), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9g;
• R12 is selected from:
• hydrogen;
• C1-6 alkyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, —CN, —OH, —OR10h —N(R10h)2, —NO2, —C(O)R10h, —SR10h, and —S(O)R10h;
• and
• C3-6 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —CN, —OH, —OR10h, —N(R10h)2, —NO2, —C(O)R10h, —SR10h, and —S(O)R10h;
• or
• R12, R11, and R2 come together to form a C5-C10 bridged ring system;
• each R9a is independently selected from:
• halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), and —CN;
• each R9b is independently selected from:
• halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), and —CN;
• each R9b′ is independently selected from:
• halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), and —CN;
• each R9c is independently selected from:
• halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —C(O)OR10c, —OC(O)R10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —C(O)OR10c, —OC(O)R10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), and —CN;
• each R9d is independently selected from:
• halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —C(O)OR10d, —OC(O)R10d, —S(O)R10d, —S(O)2R10d, —NO2, ═O, ═S, ═N(R10d), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —C(O)OR10d, —OC(O)R10d, —S(O)R10d, —S(O)2R10d, —NO2, ═O, ═S, ═N(R10d), and —CN;
• each R9g is independently selected from:
• halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), and —CN;
• and
• each R10a, R10b, R10c, R10d, R10e, R10f, R10g and R10h is independently selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.