Hydroxybenzamide derivatives and methods of use in treating diabetes
AssigneeThe Board of Regents of the University of Oklahoma
InventorsVenkateswararao Eeda, Weidong Wang
Life of this patent
Estimating the term…
Abstract
Hydroxybenzamide derivative compounds having β-cell protective activity against ER stress, and methods of their use in treating diabetes and other conditions and diseases associated with ER stress. In one non-limiting embodiment, the derivative is 3-hydroxy-N-(4-(trifluoromethyl)benzyl)benzamide.
Claims4
A method of treating a disorder or condition associated with endoplasmic reticulum (ER) stress in a subject in need of such therapy, comprising administering to the subject a hydroxybenzamide derivative compound having chemical structure I:
- wherein,
- R is selected from 3-OH, 2-OH, 4-OH, 5-OH, 2,3-diOH, 2,4-diOH, 2,5-diOH, 3,4-diOH, 3,5-diOH, and 4,5-diOH;
- and
- R1 is selected from 4-trihaloalkyl, 2-monohaloalkyl, 3-monohaloalkyl, 4-monohaloalkyl, 5-monohaloalkyl, 2-dihaloalkyl, 3-dihaloalkyl, 4-dihaloalkyl, 5-dihaloalkyl, 2-trihaloalkyl, 3-trihaloalkyl, and 5-trihaloalkyl, wherein alkyl=C1-C12, and halo is selected from chlorine (Cl), fluorine (F), bromine (Br), and iodine (I).
A method of protecting pancreatic β-cells in vitro or in vivo from ER stress-induced dysfunction and/or death, comprising administering to the pancreatic β-cells a hydroxybenzamide derivative compound having chemical structure I:
- wherein,
- R is selected from 3-OH, 2-OH, 4-OH, 5-OH, 2,3-diOH, 2,4-diOH, 2,5-diOH, 3,4-diOH, 3,5-diOH, and 4,5-diOH;
- and
- R1 is selected from 4-trihaloalkyl, 2-monohaloalkyl, 3-monohaloalkyl, 4-monohaloalkyl, 5-monohaloalkyl, 2-dihaloalkyl, 3-dihaloalkyl, 4-dihaloalkyl, 5-dihaloalkyl, 2-trihaloalkyl, 3-trihaloalkyl, and 5-trihaloalkyl, wherein alkyl=C1-C12, and halo is selected from chlorine (Cl), fluorine (F), bromine (Br), and iodine (I).
Dependencies are inferred from the claim text.