Compound as a UBR box domain ligand
AssigneeAutotac Inc.
InventorsYong Tae Kwon, Hyun Tae Kim, Jeong Eun Na, Yu Jin Seo, Chang Hoon Ji, Ha Rim Choi, Ji Eun Lee, Ah Jung Heo
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Abstract
The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.
Claims9
A compound or a salt thereof, having the structure of formula 1:
- wherein the A1 is NH2.
A method for treating UBR related disease in a subject, the method comprising:
- administering to the subject a composition comprising a therapeutically effective amount of a compound of formula 1 or a salt thereof:
- wherein the A1 is CH3 or NH2.
A method for binding a compound or a salt thereof to a UBR box domain in a subject, the method comprising:
- administering to the subject a composition comprising a compound of formula 1 or a salt thereof:
- wherein the A1 is CH3 or NH2.
Dependencies are inferred from the claim text.