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US 12,508,438 B2Granted
System and method for cold plasma therapy with HER-family receptors
AssigneeUS Patent Innovations, LLC
InventorsXiaoqian Cheng, Jerome Canady
Life of this patent
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Abstract
A system and method for using a concomitant effect of cold atmospheric plasma and Trastuzumab to overcome Trastuzumab invalidity or resistance and enhances the outcome of breast cancer therapy in both HER2-positive and negative cancer cells.
Claims3
A method for treating breast cancer comprising:
- treating HER2-negative breast cancer cells with Trastuzumab at a median infective dose (ID50) value for the Trastuzumab;
- and
- treating said HER2-negative breast cancer cells with cold atmospheric plasma at a median infective dose (ID50) value for the cold atmospheric plasma treatment to overcome Trastuzumab invalidity or resistance and to enhance the outcome of the Trastuzumab treatment.
A method for treating breast cancer cells, comprising:
- treating first samples of a breast cancer cell line with Trastuzumab at various dosages;
- calculating a median infective dose (ID50) value for Trastuzumab with a processor based on results of said treating first samples and storing the calculated values in an electronic storage;
- treating second samples of the breast cancer cell line with cold atmospheric plasma at various settings;
- calculating an ID50 value for the cold atmospheric plasma treatment with a processor based on results of said treating second samples and storing the calculated values in an electronic storage;
- and
- treating cancer cells concomitantly with Trastuzumab and cold atmospheric plasma at the stored ID50 values.
3 more elements
Dependencies are inferred from the claim text.