Closed-loop vagus nerve stimulation for the treatment of obesity

A system comprising:

• one or more implantable recording electrodes configured to be implanted within a patient's body to record vagal activity signals from a portion of one or more subdiaphragmatic branches of a patient's vagus nerve;
• an external processing device coupled to the one or more implantable recording electrodes and one or more implantable stimulating electrodes and configured to receive user inputs, the processing device further configured to:
• during a training period:
• receive one or more user inputs indicating times of hunger, amount and length of food intake, and/or satiety feelings after meals of the patient and the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve, and
• match at least a portion of spike clusters of the vagal activity signals with each of the times of hunger, amount and length of food intake, and/or satiety feelings after meals;
• and
• after the training period;
• receive the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve,
• perform signal processing to decode the vagal activity signals from the portion of the one or more subdiaphragmatic branches of the patient's vagus nerve into a hunger, eating, and/or satiation event based on the match, and
• configure a stimulation of an optimal type and timing based on the hunger, eating, and/or satiation event to decrease the patient's hunger and/or increase the patient's satiety;
• and
• the one or more implantable stimulating electrodes configured to be implanted within the patient's body to deliver the configured stimulation to another portion of one or more subdiaphragmatic branches of the patient's vagus nerve to decrease the patient's hunger and/or increase the patient's satiety.