Solid forms for tissue repair
AssigneeCartiheal (2009) Ltd.
InventorsNir Altschuler, Razi Vago
Life of this patent
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Abstract
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
Claims18
A bi-phasic scaffold for tissue repair, said bi-phasic scaffold having two phases wherein:
- a first phase of said two phases comprises solid coral and said first phase further comprises a series of hollows each extending in the same orientation along a longitudinal axis in said first phase;
- a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of hollows;
- wherein said hollows have a diameter ranging from about 125 to 650 mm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm.
A method of inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof, said method comprising implanting in a subject, a bi-phasic scaffold within a site in need of repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof in said subject, wherein said bi-phasic scaffold has two phases wherein:
- a first phase of said two phases comprises solid coral and said first phase further comprises a series of hollows each extending in the same orientation along a longitudinal axis in said first phase;
- and
- a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of hollows,
- wherein said hollows have a diameter ranging from about 125 to 650 μm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm.
A method of inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof, said method comprising:
- implanting in a subject, a bi-phasic scaffold within a site in need of repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof in said subject, said bi-phasic scaffold has two phases:
- a first phase of said two phases comprising solid coral and a series of straight hollows each extending in the same orientation along a longitudinal axis in said first phase;
- and
- a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of straight hollows, wherein the biphasic scaffold includes a tapered outer sidewall;
- wherein said straight hollows have a diameter ranging from about 125 to 650 μm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm, wherein said first phase is atop said second phase, and wherein said bi-phasic scaffold is positioned such that said first phase is implanted within or proximally to cartilage tissue and said second phase is implanted within or proximally to bone tissue.
Dependencies are inferred from the claim text.