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US 12,508,315 B2Granted
Use of vitamin E TPGS as a taste masking agent for bitter drugs
AssigneeHyloris Developments SA
InventorAtul Patil
Life of this patent
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Abstract
The invention involves novel, oral solutions of bitter drugs using Vitamin E TPGS as a masking agent and methods of using the same (e.g., for treating attention deficit/hyperactivity disorder (ADHD)). Atomoxetine (e.g., Atomoxetine HCl) is an example of a bitter drug whose bitterness can be masked by the presence of Vitamin E TPGS alone or in combination with additional ingredients.
Claims17
An atomoxetine solution, comprising:
- a) about 4-8 mg/mL atomoxetine;
- b) about 12.5-25 mg/mL Vitamin E TPGS;
- c) about 25-120 mg/mL of propylene glycol;
- d) a preservative comprising:
- i) about 1.5-2 mg/mL of methyl paraben;
- and,
- ii) about 0.1-0.4 mg/mL of propyl paraben;
- and,
- e) about 4-6 mg/mL of sucralose;
- a flavoring agent, comprising about 1-3 mg/mL of cherry flavor;
- and,
- g) water;
- wherein orange flavor and peppermint flavor are absent from the solution;
- wherein sodium benzoate is absent from the solution;
- and,
- wherein the solution is formed from atomoxetine or a pharmaceutically acceptable salt thereof.
13 more elements
An atomoxetine solution, consisting essentially of:
- a) about 4-8 mg/mL atomoxetine;
- b) about 12.5-25 mg/mL Vitamin E TPGS;
- c) about 25-120 mg/mL of propylene glycol;
- d) a preservative comprising:
- i) about 1.5-2 mg/mL of methyl paraben;
- and,
- ii) about 0.1-0.4 mg/mL of propyl paraben;
- and,
- e) about 4-6 mg/mL of sucralose;
- f) a flavoring agent, comprising about 1-3 mg/mL of cherry flavor;
- and,
- g) water;
- wherein:
- the solution is formed from atomoxetine or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.