Compositions and methods of use thereof for treatment of metabolic diseases and related disorders
AssigneeWashington University
InventorsBrian J. Debosch, Cassandra Higgins, Yiming Zhang, Allyson Mayer
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Abstract
The present disclosure relates to compositions and methods of using the same for the treatment of various metabolic diseases and related disorders (e.g. diabetes mellitus, NAFLD, obesity, metabolic syndrome). The compositions and methods of the disclosure relate to the administration of an arginine-degrading enzyme.
Claims11
A method for treating a metabolic disease selected from the group consisting of hepatic steatosis, hepatic inflammation, insulin resistance, and adiposity in a human subject in need thereof comprising administering to the subject a composition comprising a therapeutically effective amount of an Adeno-associated virus serotype 8 (AAV8) vector comprising a nucleic acid sequence encoding an arginase II.
Dependencies are inferred from the claim text.