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US 12,508,275 B2Granted
Neomycin based compounds, and pharmaceutical use thereof
AssigneesUniversité CôTe D'Azur, Centre National De La Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Centre Hospitalier Universitaire De Nice
InventorsThierry Virolle, Maria Duca, Duc Duy Vo, Laurent Turchi, Hervé Chneiweiss, Marie-Pierre Junier
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Abstract
The present invention relates to the field of medicine, in particular of oncology. Especially, it provides new compounds useful in the treatment of various cancers, such as glioblastoma, colorectal or breast cancers. The present disclosure also relates to pharmaceutical compositions containing the disclosed compounds.
Claims15
A compound of general formula (I):
- wherein X is selected in the group consisting of:
- and wherein R is represented below:
- with n being an integer from 1 to 6;
- and R1 being a —NHR2, —NR3R4, or a guanidyl group;
- R2 is a hydrogen atom, an amine protecting group, or an aminoalkyl group;
- R3 and R4, identical or different, are independently a hydrogen atom, an amine protecting group, or an aminoalkyl group;
- where any amine group being optionally protected by any amine protecting group;
- or a salt, stereoisomer, a racemic mixture, geometric isomers, or a mixture thereof.
5 more elements
Dependencies are inferred from the claim text.