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US 12,508,255 B2Granted
Methods and products for improving sperm quality
AssigneeThe University of Adelaide
InventorsRebecca Louise Robker, Macarena Bermudez Gonzalez
Life of this patent
Estimating the term…
Abstract
Disclosed are methods and products for improving the quality of sperm, methods for treating subjects to improve sperm quality or improve fertility, and use of sperm with improved quality in assisted reproductive technologies, including exposing the sperm to BGP-15 and/or a derivative thereof, such as BGP-15, propanolol, bimoclomol, arimoclomal, NG94, iroxanadine, and/or a pharmaceutically acceptable derivative, prodrug, solvate, salt, tautomer, stereoisomer, and/or racemate thereof.
Claims13
A method of improving sperm quality, the method comprising:
- incubating a population of sperm within a media comprising BGP-15 or a salt thereof in vitro for an effective duration of time at an effective dose, thereby improving one or more indicators of sperm quality selected from sperm motility, viability, DNA integrity, and mitochondrial function, as compared to a population of sperm incubated within a same media in vitro for the same effective duration but without the BGP-15 or salt thereof within the media.
Dependencies are inferred from the claim text.