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US 12,508,225 B2Granted
Lipid compound and use thereof in delivery of nucleic acid
AssigneeBeijing Tricisionbio Therapeutics Inc.
InventorsYaoxin Lin, Chengqiang Gao, Shiyou Li, Hao Wang, Lei Wu, Qi Xin
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Abstract
Provided are an ionizable lipid compound with an adjacent cis-double bond structure, a preparation method therefor, and the use thereof in the delivery of an active therapeutic agent (e.g., a nucleic acid). The ionizable lipid compound can provide a higher encapsulation rate of active substances and a better cell or in vivo transfection rate, and is particularly suitable for preparing nanoparticles with a solid structure.
Claims7
A compound having a structure
- of formula I, wherein:
- Q is
- wherein x and y are 2;
- R7 is methyl;
- R1, R2, R3, and R4 are identical or different and are each independently hydrogen or
- with the proviso that at least two of R1, R2, R3, and R4 are
- R6 is —OH;
- n is selected from integers from 1 to 8, m is selected from integers from 0 to 8, and n and m are the same or different.
5 more elements
Dependencies are inferred from the claim text.