US 12,508,073 B2 · Systems, devices, and methods for tissue layer removal

Abstract

The present disclosure provides systems, devices, and methods for penetrating a biological membrane. The system may comprise a laser unit configured to generate one or more laser beams. The system may comprise a set of targeting optics configured to direct the one or more laser beams to a target region of the biological membrane. The system may comprise a raster scanner operatively coupled to the laser unit and the set of targeting optics. The system may comprise a non-transitory computer readable storage medium comprising a set of instructions. The set of instructions may be configured to control at least one of the laser unit, the set of targeting optics, or the raster scanner to photodisrupt the target region of the biological membrane to a target depth while minimizing damage to one or more blood vessels in proximity to the target region.

Claims22

Dependent claims

A method of penetrating a biological membrane in proximity to a subject's brain, comprising:

(a) identifying a target region of the biological membrane;
(b) photodisrupting the target region to a target depth to remove or ablate at least a portion of the biological membrane to expose underlying brain tissue, wherein the biological membrane is a pia mater, wherein the photodisrupting comprises using at least one light source and one or more optical elements, and wherein the at least one light source emits one or more pulses with a pulse energy density from about 1 μJ/cm2 to about 100 J/cm2;
and
(c) inserting an implantable device comprising one or more high aspect ratio structures through the photodisrupted target region into a tissue below the biological membrane, wherein the tissue below the biological membrane comprises the underlying brain tissue, wherein the implantable device is configured to receive or transmit signals to the subject's brain.

1 more element

Dependencies are inferred from the claim text.

Systems, devices, and methods for tissue layer removal

Life of this patent

Systems, devices, and methods for tissue layer removal

Life of this patent

Abstract

Claims22