Miniaturized noninvasive glucose sensor and continuous glucose monitoring system
AssigneeMedtronic MiniMed, Inc.
InventorsLi Zhou, Raymond M. Russell, Peter Schultz, Anuj M. Patel, Carol Chen, Roshanne Malekmadani, Lynette To, Hsiao-Yu S. Kow, Raghavendhar Gautham
Life of this patent
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Abstract
Systems and methods are described herein for utilizing a photoacoustic sensor for estimating analyte concentration levels. Also described here are training methods for training an analyte sensor to more accurately estimate an analyte concentration level on the basis of a received acoustic signal.
Claims20
A photoacoustic method for estimating analyte concentration levels in a target, the method comprising:
- measuring, with a control circuit enclosed in a case of an analyte monitor, an impedance of the target via electrical impedance spectroscopy;
- irradiating, with a light source enclosed in the case of the analyte monitor, the target with light of a first wavelength;
- obtaining, with an acoustic sensor and a resonance chamber enclosed in the case of the analyte monitor, a primary acoustic signal generated by the target in response to the irradiation of the target with the light of the first wavelength, wherein both the light source and the acoustic sensor face a surface of the target, and wherein the acoustic sensor at least partially extends into the resonance chamber;
- and
- estimating, with the analyte monitor, an analyte concentration level in the target based on both of the obtained primary acoustic signal and the measured impedance of the target.
A photoacoustic method for estimating analyte concentration levels in a target, the method comprising:
- applying, using a heating element and a control circuit enclosed in a case of an analyte sensor, heat to the target;
- measuring, with a thermal sensor and the control circuit enclosed in the case of the analyte sensor, a thermal response of the target to the applied heat;
- irradiating, with a light source enclosed in the case of the analyte sensor, the target with light of a first wavelength;
- obtaining, with an acoustic sensor and a resonance chamber enclosed in the case of the analyte sensor, a primary acoustic signal generated by the target in response to the irradiation of the target with the light of the first wavelength, wherein both the light source and the acoustic sensor face a surface of the target, and wherein the acoustic sensor at least partially extends into the resonance chamber;
- and
- estimating, with the control circuit of the analyte sensor, an analyte concentration level in the target based on both of the obtained primary acoustic signal and the measured thermal response.
A photoacoustic method for estimating analyte concentration levels in a target, the method comprising:
- irradiating the target with light of a first wavelength from a light emitter enclosed in a case of an analyte sensor;
- obtaining, with an acoustic sensor and a resonance chamber enclosed in the case of the analyte sensor, a primary acoustic signal generated by the target in response to the irradiation of the target with the light of the first wavelength, wherein both the light emitter and the acoustic sensor face a surface of the target, and wherein the acoustic sensor at least partially extends into the resonance chamber;
- irradiating the target with light of a second wavelength;
- obtaining, with the acoustic sensor and the resonance chamber, a secondary acoustic signal generated by the target in response to the irradiation of the target with the light of the second wavelength;
- determining, by a signal processor enclosed in the case of the analyte sensor and based on the obtained secondary acoustic signal, an estimated background absorption level of light;
- and
- estimating an analyte concentration level in the target based on both of the obtained primary acoustic signal and the estimated background absorption level of light.
Dependencies are inferred from the claim text.