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US 12,507,900 B2Granted
Pressure based structural heart assessment systems and methods
AssigneeOpsens Inc.
InventorsSébastien Lalancette, Thomas Goodhart, Maxime Picard Deland, Claude Belleville
Life of this patent
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Abstract
The heart valve assessment systems described herein advantageously provide indicators of a heart valve condition, such as a pressure gradient or a valve regurgitation index. The heart valve assessment systems can provide indicators of a heart valve condition during a heart procedure. A pressure gradient indicates a severity or measurement of the narrowing (or stenosis) of a valve by the increase in pressure behind it. A valve regurgitation index indicates a leakiness measurement of a valve.
Claims13
A system comprising:
- a pressure guidewire comprising:
- an outer tube,
- a core wire, and
- a first pressure sensor, wherein the first pressure sensor is positioned radially between a reduced diameter portion of the core wire and a coil portion of the outer tube;
- a second pressure sensing device comprising a second pressure sensor;
- a non-transitory computer storage medium configured to at least store computer-executable instructions;
- and
- one or more hardware processors in communication with the non-transitory computer storage medium, the one or more hardware processors configured to execute the computer-executable instructions to at least:
- calibrate the second pressure sensor relative to the first pressure sensor while (i) the first pressure sensor is positioned in a first portion of a heart and (ii) the second pressure sensor is positioned in a cardiovascular region adjacent to the first portion of the heart, wherein to calibrate the second pressure sensor relative to the first pressure sensor further comprises:
- determine a first plurality of pressure values from the first pressure sensor positioned in the first portion of the heart;
- determine a second plurality of pressure values from the second pressure sensor in the cardiovascular region adjacent to the first portion of the heart;
- detect a dicrotic notch feature in the first plurality of pressure values;
- identify a timestamp corresponding to the dicrotic notch feature;
- determine, from the first plurality of pressure values, a first value at the timestamp;
- determine, from the second plurality of pressure values, a second value at the timestamp;
- and
- determine a gain adjustment based at least in part on the first value and the second value;
- determine a third plurality of pressure values from the first pressure sensor positioned in the first portion of the heart;
- determine a fourth plurality of pressure values from the second pressure sensor positioned in the cardiovascular region adjacent to the first portion of the heart, wherein to determine the fourth plurality of pressure values further comprises:
- apply the gain adjustment to an initial plurality of pressure values from the second pressure sensor;
- detect a first feature in the third plurality of pressure values;
- detect a second feature in the fourth plurality of pressure values;
- determine a heart valve condition based at least in part on the first feature and the second feature;
- and
- display the heart valve condition on a user interface.
22 more elements
A system comprising:
- a pressure guidewire comprising:
- an outer tube,
- a connector tube positioned radially inward of the outer tube,
- a core wire positioned radially inward of the outer tube, and
- a pressure sensor assembly comprising a first pressure sensor and a pressure wire lead extending from the first pressure sensor toward a proximal end of the pressure guidewire, the first pressure sensor being distal of a distal end of the connector tube;
- a second pressure sensing device comprising a second pressure sensor;
- and
- one or more hardware processors configured to at least:
- calibrate one of the first pressure sensor or the second pressure sensor relative to the other one of the first pressure sensor or the second pressure sensor while (i) the first pressure sensor is positioned in a first portion of a heart and (ii) the second pressure sensor is positioned in a cardiovascular region adjacent to the first portion of the heart, wherein to calibrate the second pressure sensor relative to the first pressure sensor further comprises:
- determine a first plurality of pressure values from one of the first pressure sensor or the second pressure sensor;
- determine a second plurality of pressure values from the other one of the first pressure sensor or the second pressure sensor;
- detect a first dicrotic notch feature in the first plurality of pressure values;
- identify a timestamp corresponding to the dicrotic notch feature;
- determine, from the first plurality of pressure values, a first value at the timestamp;
- determine, from the second plurality of pressure values, a second value at the timestamp;
- and
- determine a gain adjustment based at least in part on the first value and the second value;
- determine a third plurality of pressure values from one of the first pressure sensor or the second pressure sensor;
- determine a fourth plurality of pressure values from the other one of the first pressure sensor or the second pressure sensor, wherein to determine the fourth plurality of pressure values further comprises:
- apply the gain adjustment to an initial plurality of pressure values from the other one of the first pressure sensor or the second pressure sensor;
- detect a first feature in the third plurality of pressure values;
- detect a second feature in the fourth plurality of pressure values;
- determine a heart valve condition based at least in part on the first feature and the second feature;
- and
- display the heart valve condition on a user interface.
22 more elements
Dependencies are inferred from the claim text.