Animal model for oxidative stress research and use thereof
AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsYoung-Ki Paik, Hae Lim Jeong, Jun Young Park, Soo Han Bae, Jeong Su Park
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Abstract
The present invention relates to an animal model for oxidative stress research and use thereof, and more specifically, the present invention can utilize a mutant of RCAT having a regulatory function for an antioxidant stress regulator in Caenorhabditis elegans and a human cell line expressing RCAT as animal and human cell line models for oxidative stress research, using the mutant and the human cell line.
Claims6
A model for oxidative stress research, selected from a group consisting of Caenorhabditis elegans R02D3.7 (ok1745) comprising a regulator of cat (RCAT) gene deletion mutant having a base sequence of SEQ ID NO:
- 1;
- and a human HEK293T cell line expressing RCAT and Nrf2,
- wherein the human HEK293T cell line expressing RCAT and Nrf2 is transfected with a wild-type RCAT gene derived from Caenorhabditis elegans and a human Nrf2 gene.
An antioxidant composition comprising a regulator of cat (RCAT) gene having a base sequence of SEQ ID NO:
- 2 or 3.
Dependencies are inferred from the claim text.