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US 12,504,424 B2Granted
Systems and methods for in-vitro modeling of neurodegenerative diseases
AssigneeTechnion Research & Development Foundation Limited
InventorsInbal Maniv, Michael H. Glickman
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Abstract
The present invention is directed to a system including neurons over-expressing UBB+1, organized in a 3-dimensional culture, and method of using same. A process for making the system of the invention is also provided.
Claims11
A method for determining the efficacy of a test substance on a neurodegenerative disease, the method comprising the steps of:
- (a) contacting an in-vitro system with an effective amount of a test substance, wherein the in-vitro system comprises a three-dimensional culture comprising a cell population, and wherein at least 70% of said cell population are genetically modified neurons expressing a Ubiquitin-B+1 (UBB+1) polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 1, and
- (b) determining in said in-vitro system a responsive change in at least one characteristic of a neurodegenerative disease,
- thereby determining the test substance efficacy on said neurodegenerative disease.
1 more element
Dependencies are inferred from the claim text.