Purification of actinium
AssigneeSck.Cen
InventorsDominic Maertens, Karen Van Hecke, Thomas Cardinaels
Life of this patent
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Abstract
A method for purifying Ac from a mixture includes Ac and at least one element selected from Ra, Pb, Po, Bi and La. The method includes the steps of: (a) performing a first separation using a first extraction chromatographic column based on a first resin (either a diglycolamide resin or a dialkylphosphoric acid resin) and a first matrix solution; and (b) performing a second separation using a second extraction chromatographic column based on a second resin (respectively either a dialkylphosphoric acid resin or a diglycolamide resin).
Claims12
A method for purifying Ac from a mixture comprising Ac and at least one element selected from Ra, Pb, Po, Bi and La, the method comprising:
- a. performing a first separation, comprising
- a1. loading the mixture on a first extraction chromatographic column based on a first resin and a first matrix solution,
- a2. washing the mixture loaded on the first extraction chromatographic column with a first washing solution, and
- a3. eluting the mixture loaded on the first extraction chromatographic column with a first eluent to obtain a first eluate;
- and
- b. performing a second separation, comprising
- b1. loading the first eluate on a second extraction chromatographic column based on a second resin and a second matrix solution,
- b2. washing the first eluate loaded on the second extraction chromatographic column with a second washing solution, and
- b3. eluting the first eluate loaded on the second extraction chromatographic column with a second eluent to obtain a second eluate containing the purified Ac;
- wherein either
- the first resin is a diglycolamide resin, the first matrix solution has a pH between −0.8 and 0, the first washing solution has a pH between −0.8 and 0 and the first eluent has a pH between 1 and 4, and
- the second resin is a dialkyl phosphoric acid resin, the second matrix solution has a pH between 1 and 4, the second washing solution has a pH between 1 and 4 and the second eluent has a pH between −0.8 and 0;
- or
- the first resin is a dialkyl phosphoric acid resin, the first matrix solution has a pH between 1 and 4, the first washing solution has a pH between 1 and 4 and the first eluent has a pH between −0.8 and 0, and
- the second resin is a diglycolamide resin, the second matrix solution has a pH between −0.8 and 0, the second washing solution has a pH between −0.8 and 0 and the second eluent has a pH between 1 and 4,
- wherein the first eluate obtained in step a3 is loaded immediately onto the second extraction chromatographic column in step b1, by forming a tandem between the first and the second extraction chromatographic column.
Dependencies are inferred from the claim text.