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US 12,503,718 B2Granted
Biomarker and treatment target for alcoholic hepatitis
AssigneeThe Regents of the University of California
InventorsBernd Schnabl, Ana Cristina Llorente Izquierdo
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Abstract
Methods of detecting and monitoring the progression of liver disease, including time to death, and methods of treating liver disease, in a mammal are provided.
Claims10
A method comprising:
- obtaining a fecal, liver, or blood sample from a mammal infected with liver cirrhosis or hepatitis,
- detecting or determining a presence or an amount of Enterococcus faecalis cytolysin or cytolytic Enterococcus faecalis in the sample;
- selecting a mammal with 2 fold, 5 fold, 10 fold, 100 fold, or 1000 fold greater amount of Enterococcus faecalis cytolysin or cytolytic Enterococcus faecalis than a control mammal;
- and
- treating the selected mammal by administering to the mammal an effective amount of a composition comprising one or more lytic phage specific for Enterococcus faecalis.
2 more elements
Dependencies are inferred from the claim text.