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US 12,503,559 B2Granted
Elastomeric nanocomposite hydrogels
AssigneeCase Western Reserve University
InventorsEben Alsberg, Oju Jeon
Life of this patent
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Abstract
An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.
Claims18
A composition comprising:
- an elastomeric nanocomposite hybrid hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromers and the first natural polymer macromers are ionically crosslinked with a plurality of inorganic nanoparticles, wherein the plurality of inorganic nanoparticles ionically form reversible physical crosslinks with carboxylic groups of the first natural polymer macromers;
- the elastomeric nanocomposite hybrid hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products;
- wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides, which are optionally oxidized and the second natural polymer macromers include an acrylate group and/or methacrylate group;
- and
- wherein the acrylate and/or methacrylate groups of the first natural polymer macromers react with the acrylate and/or methacrylate groups of the second natural polymer macromers polymers to form the covalent crosslinks.
2 more elements
A composition comprising:
- an elastomeric nanocomposite hybrid hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromers and the first natural polymer macromers are ionically crosslinked with a plurality of inorganic nanoparticles, wherein the plurality of inorganic nanoparticles ionically form reversible physical crosslinks with carboxylic groups of the first natural polymer macromers;
- the elastomeric nanocomposite hybrid hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products, and wherein the elasticity of the elastomeric nanocomposite hybrid hydrogel is substantially maintained during degradation;
- and
- wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides, which are optionally oxidized;
- the second natural polymer macromers are different from the first natural polymer macromers and include an acrylate group and/or methacrylate group;
- and wherein the acrylate and/or methacrylate groups of the first natural polymer macromers react with the acrylate and/or methacrylate groups of the second natural polymer macromers to form the covalent crosslinks.
3 more elements
Dependencies are inferred from the claim text.