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US 12,503,499 B2Granted
Modified HIV-1 proviral vectors with enhanced dendritic cell transduction efficiencies comprising the JRFL envelope
AssigneeUniversity of Massachusetts
InventorJeremy Luban
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Abstract
The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments thereof in a mammalian subject. The methods comprise administering a virus or virus-like particle to a mammal comprising heterologous immune cells and isolating a population of immunoglobulin-producing cells from the mammal, thereby producing the antibodies or antibody fragments thereof.
Claims13
An isolated nucleotide sequence having at least about 95% identity over the entire length of its coding sequence compared to the coding sequence of SEQ ID NO:
- 7, 8, or 9, wherein an amino acid sequence encoded by the coding sequence of the isolated nucleotide sequence is identical to an amino acid sequence encoded by the coding sequence of SEQ ID NO:
- 7, 8, or 9, respectively.
Dependencies are inferred from the claim text.