Rabbit haemorrhagic disease virus (RHDV) vaccines
OwnerAlan John Younginventor
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Abstract
The present invention describes immunogenic compositions containing immunogenic polypeptides of Rabbit Haemorrhagic Disease Virus (RHDV), including immunogenic compositions containing antigens other than RHDV antigens, including antigens that may be used in immunization against pathogens that cause diarrheal diseases. Methods of eliciting an immune response with the immunogenic compositions as disclosed and methods of treating a RHDV infection are also described.
Claims18
A method for producing RHDV-derived immunogenic polypeptides and/or peptides, comprising culturing a host cell transformed with a nucleic acid under conditions which induce expression of said polypeptides and/or peptides, wherein the polypeptides and/or peptides comprise the amino acid sequence as set forth in SEQ ID NO:
- 2 or comprise an amino acid sequence having at least between 95% to about 99.9% identity to SEQ ID NO:2, and optionally, mixing or co-expressing said immunogenic polypeptides and/or peptides with one or more adjuvants.
An immunogenic composition comprising the polypeptide as set forth in SEQ ID NO:2 or a polypeptide having at least between 95% to about 99.9% identity to SEQ ID NO:2.
An isolated recombinant nucleic acid encoding a RHDV VP1 protein, wherein the encoding nucleic acid comprise i) a sequence as set forth in SEQ ID NO:
- 1 or ii) nucleic acid having at least 80% sequence identity to the nucleic acid sequences as set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.