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US 12,503,485 B2Granted
Human aminosterol ENT-03 compounds, related compositions comprising the same, and methods of using the same
AssigneeEnterin, Inc.
InventorsDenise Barbut, Michael Zasloff
Life of this patent
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Abstract
The present application relates generally to novel aminosterol compounds, compositions comprising the same, and methods of making and using the novel aminosterol compounds and compositions.
Claims10
An aminosterol compound having the formula:
- wherein:
- R1 is H or D;
- and
- R2 is H or D;
- provided that all of R1 are H, all of R2 are H, or all of R1 and R2 are H,
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof.
3 more elements
An aminosterol compound:
- (a) having the formula:
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
- or
- (b) having the formula:
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
- or
- (c) having the formula:
- wherein:
- R1 is H, an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, and optionally substituted C1-C6 alkenyl;
- and
- R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
- provided that at least one of R1 and R2 is not H,
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
- or
- (d) having the formula:
- wherein:
- R1 is H, an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, and optionally substituted C1-C6 alkenyl;
- and
- R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
- provided that at least one of R1 and R2 is not H, or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
- or
- (e) having the formula:
- wherein:
- R1 is H, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
- and
- R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
- provided that at least one of R1 and R2 is not H,
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof.
25 more elements
An aminosterol compound having the formula:
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
- or
- or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof.
Dependencies are inferred from the claim text.