Androstane derivatives with activity as pure or predominantly pure stimulators of SERCA2a for the treatment of heart failure

A compound having a formula (I)

• wherein:
• X is selected from the group consisting of a carboxylic acid, carboxylic ester or a bioisoster thereof, primary alcohol, ester, and an amine group, wherein the bioisoster consists of a sulfate, sulfonic acid, phosphate, phosphonate, or a nitrogen-containing heterocyclic ring;
• n is 1, 2, 3, 4, or 5;
• a C3-C1′ dashed line represents an optional exocyclic double bond C═C at position C3-C1′;
• a C2-C3 dashed line represents an optional endocyclic double bond C═C;
• Y at C6 is a hydroxyl (OH) in the alpha- or beta-configuration or a hydroxymethyl (CH2OH) in the alpha-configuration;
• Z at C7 is a —H or —OH in an alpha-configuration or a ketone, wherein a dashed line represents an optional carbonyl group (C═O) at Z;
• or
• a pharmaceutically acceptable salt, solvate, or hydrate thereof.