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US 12,503,482 B2Granted
Compositions and methods for trehalose phospholipids
AssigneesThe Brigham and Women's Hospital, Inc., Rijksuniversiteit Groningen
InventorsIldiko Van Rhijn, Adriaan J. Minnaard, D. Branch Moody, Tan-Yun Cheng, Jeffrey Buter
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Abstract
Provided herein are compositions of trehalose phospholipids and uses thereof, e.g., compounds and compositions comprising 6,6′-diphosphatidyltrehalose (diPT) and analogs thereof with modifications of the diPT chemical scaffold, that bind and agonize Mincle, and the use thereof as adjuvants.
Claims10
A compound of Formula (IV)
A composition comprising a compound of Formula (I):
- wherein R1 is a saturated or unsaturated fatty acid alkyl and R2 is a saturated or unsaturated fatty acid alkyl, a pharmaceutically acceptable carrier, and an antigen.
Dependencies are inferred from the claim text.