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US 12,503,479 B2Granted
Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
AssigneeCellectar Biosciences, Inc.
InventorJarrod Longcor
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Abstract
Disclosed herein are phospholipid ether (PLE) molecules. Further provided are phospholipid-flavagline conjugates. The phospholipid-flavagline conjugate may include a PLE conjugated to a flavagline via a linker. Further provided herein are methods of treating cancer in a subject and methods of targeting a drug to a tumor or cancer cell in a subject.
Claims12
A conjugate according to Formula II, or a salt thereof:
- wherein X is,
- or methylene, or bond;
- Y is a linker comprising a disulfide;
- and
- Z is a flavagline anti-cancer drug.
2 more elements
Dependencies are inferred from the claim text.