Nitroxoline derivative, preparation method therefor, and use thereof

A compound of formula (I) or a pharmaceutically acceptable salt thereof,

• R1 is —NRaRb;
• Ra and Rb are each independently selected from the group consisting of hydrogen and C1-C6 alkyl;
• or, Ra and Rb together with the nitrogen atom to which they are attached form a 5- to 7-membered nitrogen-containing heterocyclyl, the 5- to 7-membered nitrogen-containing heterocyclyl optionally comprises one or more heteroatom(s) selected from the group consisting of N, O and S in addition to N;
• and the 5- to 7-membered nitrogen-containing heterocyclyl is optionally further substituted by one or more Qs;
• Q is halogen, oxo, C1-C6 alkyl,—C(O) Rc, —C(O)ORc,—C(O)NRcRd,—C(O)N(Rc)(CH2)qRd or —S(O)pRc;
• Rc and Rd are each independently selected from the group consisting of hydrogen and C1-C6 alkyl, wherein the C1-C6 alkyl is optionally further substituted by one or more halogens;
• or, Rc and Rd together with the nitrogen atom to which they are attached form a 5- to 7-membered nitrogen-containing heterocyclyl, the 5- to 7-membered nitrogen-containing heterocyclyl optionally comprises one or more heteroatom(s) selected from the group consisting of N, O and S in addition to N, the 5- to 7-membered nitrogen-containing heterocyclyl is optionally further substituted by one or more substituent(s) selected from the group consisting of halogen and C1-C6 alkyl;
• p is 1 or 2;
• q is an integer from 0 to 6;
• or,
• R1 is C3-C10 cycloalkyl, wherein the C3-C10 cycloalkyl is optionally further substituted by one or more substituent(s) selected from the group consisting of halogen and C1-C6 alkyl;
• or,
• R1 is selected from the group consisting of C6-C10 aryl and 5- to 10-membered heteroaryl, wherein the C6-C10 aryl and 5- to 10-membered heteroaryl are optionally further substituted by one or more substituent(s) selected from the group consisting of halogen and C1-C6 alkyl;
• R2 is hydrogen;
• R3 is hydrogen;
• R4 is hydrogen;
• R5 is hydrogen.