Regional decoagulation system for extracorporeal blood-circulation circuit

A system for regional decoagulation of the blood in an extracorporeal circulation circuit comprising a line for drawing the blood from the patient, a filtration unit for separating plasma water, a line for reintroducing the blood into the patient defining a main circuit, the system further comprising:

• a first bag, a first pump, and/or a first line for infusion of a solution of a citrate or citric acid on said main circuit, which are set upstream of said filtration unit with respect to the direction of the blood flow;
• a second bag, a second pump, and/or a second line for infusion of a solution for electrolyte restoration on said main circuit, which are set downstream of said filtration unit with respect to the direction of the blood flow;
• and a secondary circuit for recirculation of the plasma water obtained by said first filtration unit, said secondary circuit comprising:
• a first cartridge comprising an anion-exchange resin charged with chlorine ions;
• a second cartridge comprising a cation-exchange resin charged with sodium and potassium ions, which is set downstream of said first cartridge in the direction of flow of the plasma water in the secondary circuit;
• a third cartridge comprising an anion resin charged with bicarbonate ions, a fourth cartridge comprising a cation resin charged with hydrogen ions, and a first oxygenator, arranged downstream of said third and said fourth cartridges in the direction of flow of the plasma water in said secondary circuit;
• and a third pump and/or a third line for removal of a first fraction of the plasma water obtained by said filtration unit.