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US 12,502,462 B2Granted
System for extended storage of red blood cells and methods of use
AssigneeHemanext Inc.
InventorsTatsuro Yoshida, Paul Vernucci
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Abstract
A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
Claims20
A method for editing and storing red blood cells comprising:
- obtaining whole blood;
- separating red blood cells from the whole blood to form packed red blood cells;
- depleting oxygen from the packed red blood cells to form depleted packed red blood cells, wherein the depleting comprises passing the packed red blood cells through a device having a disposable housing, an inlet port, an outlet port, one or more gas permeable membranes adapted to receiving and conveying red blood cells, and an oxygen sorbent;
- leukoreducing the whole blood, the packed red blood cells, or the depleted packed red blood cells;
- storing the depleted packed red blood cells under anaerobic conditions in an anaerobic storage bag comprising an outer bag having a barrier film that is impermeable to oxygen and an inner bag in contact with the red packed blood cells to form stored depleted red blood cells;
- and
- editing the stored depleted packed red blood cells to form stored edited and depleted packed red blood cells, wherein the editing comprises identifying and removing moribund, dead, or dying red blood cells from the stored depleted packed red blood cells.
4 more elements
A method for editing and storing red blood cells comprising:
- obtaining whole blood;
- separating red blood cells from the whole blood to form packed red blood cells;
- editing the packed red blood cells to form edited packed red blood cells, wherein the editing comprises identifying and removing moribund, dead, or dying red blood cells from the packed red blood cells;
- depleting oxygen from the edited packed red blood cells to form edited and depleted packed red blood cells, wherein the depleting comprises passing the packed red blood cells through a device having a disposable housing, an inlet port, an outlet port, one or more gas permeable membranes adapted to receiving and conveying red blood cells, and an oxygen sorbent;
- leukoreducing the whole blood, the packed red blood cells, the edited packed red blood cells, or the edited and depleted packed red blood cells;
- and
- storing the edited and depleted packed red blood cells under anaerobic conditions in an anaerobic storage bag comprising an outer bag having a barrier film that is impermeable to oxygen and an inner bag in contact with the red packed blood cells to form stored edited and depleted packed red blood cells.
4 more elements
Dependencies are inferred from the claim text.