Anhydrous biocompatible composite materials
AssigneeKuros Biosciences AG
InventorsFlorence De Groot-Barrere, Davide Barbieri, Dirk Wybe Grijpma, Joost De Bruijn
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Abstract
The invention is directed to biocompatible composite materials for medical applications such as tissue regeneration. In particular, the present invention is directed to biocompatible composite materials that may be used for the treatment of lost bone or bone defects. According to the invention there is provided an anhydrous biocompatible composite material comprising a biodegradable polymeric material and a granular synthetic material, wherein the polymeric material essentially consists of at least one block copolymer that comprises at least one hydrophilic block and at least one hydrophobic block.
Claims23
An anhydrous biocompatible composite putty material for bone regeneration, which is injectable or malleable into a desired shape which is retained comprising a biodegradable polymeric material and a granular synthetic material which granular synthetic material is osteoconductive and/or osteoinductive, wherein the polymeric material consists essentially of at least one block copolymer, wherein said at least one block copolymer is a polymer of formula (I)
- Xn-Bq-Ap-Bq-Xm-[BqApBq]l (I)
- wherein;
- A and B are independently polymers of methylene oxide, ethylene oxide, propylene oxide, butylene oxide, dioxanone or phenyl oxide;
- X is a polyamide, polyester, polyurethane, polycarbonate or polyester unit;
- l is 0 or 1;
- m is 1 to 7;
- n is 0 or equal to m;
- p is 2 to 150;
- q is 0 to 100;
- and
- l+n is more than 0;
- wherein said biodegradable polymeric material almost completely degrades under physiological conditions within 48 hours.
Dependencies are inferred from the claim text.