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US 12,502,437 B2Granted
Compositions and methods for therapeutic delivery
AssigneeGenVivo, Inc.
InventorsMakoto Sato, Alexander T. Cunha, Cecilia Roh, Robert G. Johnson, Jr.
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Abstract
Described herein are compositions and methods for therapeutic delivery using an engineered viral vector. The engineered viral vector provided herein can improve therapeutic delivery, increase targeting efficiency, and decrease off-targeting or adverse effects.
Claims20
An engineered viral vector comprising a modified envelope protein, wherein the modified envelope protein comprises:
- a) at least one targeting moiety, and
- b) at least one modification site in SEQ ID NO:
- 1, wherein the at least one targeting moiety is inserted at the at least one modification site;
- wherein the modified envelope protein comprises a recombinant viral envelope protein derived from Sindbis virus comprising an E3 domain and an E2 domain, and wherein the modified envelope protein comprises a protease cleavage site located at the border between the E3 and E2 domains, wherein the modified envelope protein increases transduction efficiency and specificity of the engineered viral vector to a target cell relative to a viral vector without the modified envelope protein, and wherein the engineered viral vector comprises an engineered murine leukemia viral (MLV) vector.
1 more element
Dependencies are inferred from the claim text.