Compositions for use in treatment of acne
AssigneeSanofi Pasteur Limited
InventorsNadège Arnaud Barbe, Danilo Casimiro, Andreas Karlsson, Isabelle Legastelois, Noëlle Mistretta, Geneviève Renauld, Bachra Mohamed Rokbi, Khang Tran, Monica Wu
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Abstract
This invention relates to compositions (e.g. immunogenic compositions) which can be used to immunise against C. acnes. The compositions comprise C. acnes antigens and antigen combinations, used in the form of nucleic acids (e.g. mRNAs) encoding antigenic proteins or in the form of recombinant protein antigens.
Claims68
A nucleic acid comprising a nucleotide sequence encoding a modified Cutibacterium acnes (C. acnes) Christie-Atkins-Munch-Petersen factor 2 (CAMP2) polypeptide, wherein the modified C. acnes CAMP2 polypeptide comprises an amino acid sequence comprising a C. acnes CAMP2 polypeptide sequence and a transmembrane domain sequence, wherein the nucleic acid is a messenger RNA (mRNA).
A composition comprising a nucleic acid comprising a nucleotide sequence encoding a C. acnes CAMP2 polypeptide and one or more of:
- (i) a nucleic acid comprising a nucleotide sequence encoding a C. acnes DsA1 polypeptide;
- (ii) a nucleic acid comprising a nucleotide sequence encoding a C. acnes DsA2 polypeptide;
- (iii) a nucleic acid comprising a nucleotide sequence encoding a C. acnes PITP polypeptide;
- (iv) a nucleic acid comprising a nucleotide sequence encoding a chimeric C. acnes DsA1/DsA2 polypeptide;
- and
- (v) a nucleic acid comprising a nucleotide sequence encoding a chimeric C. acnes DsA1/DsA2/PITP polypeptide.
A nucleic acid comprising a nucleotide sequence encoding a chimeric C. acnes DsA1/DsA2/PITP/CAMP2 polypeptide, wherein the chimeric C. acnes DsA1/DsA2/PITP/CAMP2 polypeptide comprises:
- (a) a chimeric C. acnes DsA1/DsA2 polypeptide;
- (b) an immunogenic fragment of a C. acnes PITP polypeptide;
- and
- (c) a C. acnes CAMP2 polypeptide or an immunogenic fragment thereof.
An immunogenic composition comprising a nucleic acid comprising a nucleotide sequence encoding a C. acnes CAMP2 polypeptide, wherein the nucleic acid is a mRNA.
A composition comprising:
- a messenger RNA (mRNA) comprising a nucleotide sequence encoding a modified C. acnes CAMP2 polypeptide comprising or consisting of a sequence according to SEQ ID NO:
- 207;
- a mRNA comprising a nucleotide sequence encoding a chimeric C. acnes DsA1/DsA2 polypeptide comprising or consisting of a sequence according to SEQ ID NO:
- 70;
- and
- a mRNA comprising a nucleotide sequence encoding a C. acnes PITP polypeptide comprising or consisting of a sequence according to SEQ ID NO:
- 73,
- wherein the mRNAs are encapsulated in an LNP.
Dependencies are inferred from the claim text.