Preservation of pancreatic islet grafts in the extrahepatic space
AssigneesThe Regents of the University of California, U.S. Government Represented by the Department of Veteans Affairs
InventorsCasey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
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Abstract
Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Claims30
A method for promoting survival of an insulin-producing cell under hypoxic and/or nutrient poor conditions, comprising:
- (i) providing a composition comprising the insulin-producing cell and a combination of factors, and wherein the combination of factors comprises at least one proangiogenic factor, gamma-aminobutyric acid (GABA), parathyroid hormone (PTH), and PTH-related peptide (PTHrP);
- and
- (ii) introducing the composition to the hypoxic and/or nutrient poor conditions, thereby promoting survival of the insulin-producing cell under the conditions.
A method for promoting survival of an insulin-producing cell in an extrahepatic space, comprising:
- (i) providing a composition comprising the insulin-producing cell and a combination of factors, wherein the combination of factors comprises at least one proangiogenic factor, GABA, PTH, and PTHrP;
- and
- (ii) introducing the composition to the extrahepatic space, thereby promoting survival of the insulin-producing cell in the extrahepatic space.
A method for promoting engraftment of an insulin-producing cell in an individual, comprising:
- (i) providing a composition comprising the insulin producing cell and a combination of factors, wherein the combination of factors comprises at least one proangiogenic factor, GABA, PTH, and PTHrP;
- and
- (ii) administering the composition to the individual, thereby promoting the engraftment of the insulin-producing cell.
A method for treating diabetes mellitus in an individual, comprising:
- (i) providing a composition comprising an insulin producing cell and a combination of factors, and wherein the combination of factors comprises at least one proangiogenic factor, GABA, PTH, and PTHrP;
- and
- (ii) administering the composition to the individual, thereby treating diabetes mellitus.
Dependencies are inferred from the claim text.