Nitrogen-containing heterocyclic compound and use thereof
AssigneeShanghai Shijiang Biotechnology Co., Ltd
InventorsYufeng Shi, Wenjiang Ma, Gang Pei, Peng Xia, Yingcai Wang
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Abstract
The present invention relates to a nitrogen-containing heterocyclic compound and the use thereof. Specifically, provided is a compound of formula I or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof. The compound has excellent and precise therapeutic effects on tumors with low expression or non-expression of the NNMT gene, high expression of DNA methylase, high expression of UHRF1, a high methylation level of nucleotide sites of the NNMT gene, and/or a high methylation level of DNACpG site in a NNMT gene region.
Claims19
A compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof;
- wherein,
- R1 and R2 are each independently hydrogen, deuterium, C1-C10 alkyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, C1-C10 haloalkyl, C6-C10 aryl, or 5-10 membered heteroaryl;
- R3 is halogen, R17—O—, or (R18R19)N—, wherein, R17 is C1-C10 alkyl,
- C3-C12 cycloalkyl-C2-C6 acyl-, C1-C10 haloalkyl, C6-C12 aryl-C1-C8 alkyl-, C6-C12 aryl-C6-C12 aryl-C1-C8 alkyl-, 5-12 membered heteroaryl-C1-C8 alkyl-, C6-C12 aryl-O-C1-C8 alkyl-, 5-12 membered heteroaryl-O-C1-C8 alkyl-, C2-C4 alkenyl-C1-C4 alkyl-C2-C4 alkenyl-C1-C4 alkyl-, C2-C4 alkenyl-C1-C4 alkyl-, or (R20R21)N-C1-C10 alkyl-;
- R4is R17—O—, wherein, R17 is C1-C8 alkyl, or C1-C8 haloalkyl;
- R5 is hydrogen;
- or R3 and R4, or R4 and R5 are connected to form
- R6 is hydrogen, or halogen;
- R7 is hydrogen, C1-C10 alkyl, C1-C10 haloalkyl, substituted or unsubstituted C6-C12 aryl-C1-C10 alkyl-, or substituted or unsubstituted 5-12 membered heteroaryl-C1-C10 alkyl-, wherein, each “substituted” means that 1, 2, 3, 4 or 5 hydrogen atoms on the group are independently substituted by substituent selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl;
- R8, R11, R12, R13, R14 and R15 are each independently hydrogen;
- R9 and R10 are connected to form
- R18 and R19 are each independently hydrogen, or C6-C12 aryl-C1-C6 alkyl-;
- or R18 and R19 are connected to form a substituted or unsubstituted 3-10 membered heterocycloalkane ring, each “substituted” means that 1, 2 or 3 hydrogen atoms on the group are independently substituted by substituent selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, halogen, C1-C6 haloalkoxyl;
- R20 and R21 are each independently hydrogen, or C2-C8 ester group;
- or R20 and R21 are connected to form a 3-10 membered heterocycloalkyl;
- R31, R32, R33, R34 and R35 are each independently hydrogen;
- R41 is hydrogen;
- W1 and W2 are each independently O;
- W3, W4, W5 and W6 are each independently O.
Dependencies are inferred from the claim text.