Implantable device for sustained release of a macromolecular drug compound

An implantable device for delivery of a macromolecular drug compound, the device comprising:

• a core having an outer surface, wherein the core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 5 kDa or more, the core polymer matrix containing a first ethylene vinyl acetate copolymer, wherein the first ethylene vinyl acetate copolymer has a vinyl acetate content of from about 25 wt. % to about 55 wt. %, wherein the core comprises from about 5 wt. % to about 60 wt. % of the drug compound;
• and
• a membrane layer positioned adjacent to the outer surface of the core, wherein the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed, the membrane polymer matrix comprising a second ethylene vinyl acetate copolymer, wherein the second ethylene vinyl acetate copolymer constitutes from about 70 wt. % to about 99 wt. % of the membrane layer, wherein the second ethylene vinyl acetate copolymer has a vinyl acetate content of from about 25 wt. % to about 55 wt. %, and wherein the implantable device has a release rate of between 0.1E+0 and 0.5E+2 μg per hour for a time period up to about 1500 hours.