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US 12,502,354 B2Granted
High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds
AssigneeNorthwestern University
InventorsStephen E. Henrich, C. Shad Thaxton, Sonbinh T. Nguyen, Bong Jin Hong
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Abstract
Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs.
Claims17
A spherical nanoparticle comprising:
- a core and a shell surrounding and attached to the core, wherein the core comprises a lipid conjugated organic core scaffold, and wherein the spherical nanoparticle is characterized by a surface zeta potential of −16 to −30 millivolts (mV) and at least one of the following:
- (a) the organic core scaffold comprising a hydrophobic small molecule-phospholipid conjugate (PL4);
- or
- (b) the organic core scaffold comprising an amphiphilic DNA-linked small molecule-phospholipid conjugate (DNA-PL4).
1 more element
Dependencies are inferred from the claim text.