Non-signaling HIV fusion inhibitors and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames L Riley, James A. Hoxie, George J. Leslie, Max W. Richardson
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Abstract
The present invention relates to engineered cells expressing a fusion protein comprising a peptide fusion inhibitor and a CXCR4 protein that lacks signaling activity. Also provided are methods of suppressing, inhibiting, preventing or treating a HIV infection in a subject in need thereof using the engineered cells.
Claims12
A fusion protein comprising a peptide fusion inhibitor and a CXCR4 protein, wherein the CXCR4 protein comprises the amino acid sequence of SEQ ID NO:
- 1 with the proviso that the CXCR4 protein further comprises substitutions D97N, R134H, and L226R which decrease signaling activity of the CXCR4 protein relative to signaling activity of a wildtype CXCR4 protein comprising the amino acid sequence of SEQ ID NO:
- 1.
An isolated nucleic acid comprising a nucleic acid sequence encoding a fusion protein comprising a peptide fusion inhibitor and a CXCR4 protein, wherein the CXCR4 protein comprises the amino acid sequence of SEQ ID NO:
- 1 with the proviso that the CXCR4 protein further comprises substitutions D97N, R134H, and L226R which decrease signaling activity of the CXCR4 protein relative to signaling activity of a wildtype CXCR4 protein comprising the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.