Biosynthesis of cannabinoids from cannabigerolic acid using novel cannabinoid synthases
AssigneeNational University of Singapore
InventorsMaybelle Darlene Kho Go, Wen Shan Yew
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Abstract
A method for producing a cannabinoid by contacting cannabigerolic acid with a cannabinoid synthase orthologue. The cannabinoid synthase orthologue is from an organism other than Cannabis sativa. Also disclosed is a recombinant cell of Saccharomyces cerevisiae or Pichia pastoris that includes in its genome a nucleic acid encoding the above cannabinoid synthase orthologue. The cannabinoid synthase orthologue is expressed in the recombinant cell in an active form.
Claims3
A method for producing one or more cannabinoids, the method comprising contacting cannabigerolic acid (CBGA) with a cannabinoid synthase orthologue, wherein the orthologue includes an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 16, 23, 47, 57, 87, 107 and 117 and wherein the cannabinoids produced have a molecular weight of 358.5 g/mol, 374.5 g/mol, or 330.5 g/mol.
Dependencies are inferred from the claim text.