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US 12,497,508 B2Granted
Branched and degradable polyethylene glycol derivative
AssigneesNof Corporation, Tokyo Institute of Technology
InventorsHiroki Yoshioka, Kazuki Osakama, Mika Hamura, Takanori Inaba, Nobuhiro Nishiyama, Makoto Matsui, Hiroyasu Takemoto, Takahiro Nomoto, Xiaohang Sun
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Abstract
An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.
Claims10
A degradable polyethylene glycol derivative represented by the following formula (1):
- wherein
- n is 45-950,
- W is an oligopeptide consisting of 5 to 47 residues and having a symmetrical structure centered on glutamic acid of formula w1, w2, or w3:
- wherein Glu is a glutamic acid residue and Z is a degradable oligopeptide selected from the group consisting of glycine-phenylalanine-leucine-glycine (SEQ ID NO:
- 1), glycine-glycine-phenylalanine-glycine (SEQ ID NO:
- 2), glycine-phenylalanine-glycine, glycine-leucine-glycine, valine-citrulline-glycine, valine-alanine-glycine, and phenylalanine-glycine,
- a is 2-8,
- X is a functional group capable of reacting with a bio-related substance, and
- L1 and L2 are each independently a divalent spacer.
6 more elements
Dependencies are inferred from the claim text.