US 12,497,382 B2 · GLP-1R modulating compounds

GLP-1R modulating compounds

AssigneeGilead Sciences, Inc.

InventorsStephen E. Ammann, Gediminas J. Brizgys, James S. Cassidy, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Michael Graupe, Chao-I Hung, Kavoos Kolahdouzan, Scott D. Schroeder, Nathan D. Shapiro, Daniel G. Shore, Suzanne M. Szewczyk, James G. Taylor, Rhiannon Thomas-Tran, Nathan E. Wright, Zheng-Yu Yang, Sheila M. Zipfel

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Abstract

The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Claims10

Dependent claims

A method of treating a GLP-1R mediated disease or condition comprising administering to a subject in need thereof a pharmaceutically effective amount of a compound, or pharmaceutically acceptable salt thereof, wherein the compound has the structure:

Dependencies are inferred from the claim text.

Facts

Application

18/195,767Filed 10 May 2023 · continuation

Priority

25 Oct 2019

Published

US 2023/0391747 A17 Dec 2023

Granted

16 Dec 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Family

Application62/926,270Us provisional application · filed 25 Oct 2019

Application63/028,187Us provisional application · filed 21 May 2020

Application17/077,729Parent of this continuation · filed 22 Oct 2020

US 2023/0391747 A1Pre-grant publication · published 7 Dec 2023

US 11,702,404 B2Parent of this continuation

US 2021/0171499 A1Published application

US 12,497,382 B2This patent

From the US filing history. Foreign family members aren’t listed.