Compound for the determination of the protein FKBP12 and a sensor unit comprising it
AssigneeUniversita' Degli Studi Di Firenze
InventorsGabriella Caminati, Piero Procacci, Stefano Menichetti, Maria Raffaella Martina, Laura Marsili
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Abstract
The present invention relates to novel compounds useful as sensors for the rapid and specific determination of the FKBP12 protein, a peptidyl-prolyl cis-trans isomerase (PPlase), the levels of which in the biological fluids of a subject change if the subject is affected by pathological conditions, in particular neurodegenerative diseases, such as the Parkinson's disease and the Alzheimer's syndrome, tumour pathologies, autoimmune diseases, or if that subject is in a phase of acute rejection after organ transplantation.
Claims21
A compound of formula (I)
- wherein
- L is selected from the group consisting of thiol, organo-sulfur group, carboxylic acid, primary amine, trichlorosilane, trimethoxysilane, triethoxysilane, cholesterol, benzene, naphthalene, anthracene, phenanthrene, and pyrene, Y is selected from —(CH2)n— and —(OCH2CH2)m—, where n is between 7 and 13 and m is between 2 and 6.
Dependencies are inferred from the claim text.