Acrylamide derivatives

A compound of formula (I):

• wherein:
• R1a is H or methyl;
• R1b is H or fluoro;
• A is group (Ab), (Ac) or (Ad):
• wherein group (Ab) is:
• wherein:
• R4 is H, C1-4alkyl or C1-4alkylene(aryl);
• wherein said aryl is optionally substituted by 1, 2 or 3 substituents each independently selected from C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, halo, CN, OH, NR4aR4b, SO2R4c and NHSO2R4c;
• R4a is selected from H and C1-4alkyl;
• R4b is selected from H, C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, aryl and 4-7 membered heterocycloalkyl;
• R4c is selected from C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, aryl and 4-7 membered heterocycloalkyl;
• R5 is H or C1-4alkyl;
• each R6 is independently C1-4alkyl or halo;
• n is 0, 1, 2 or 3;
• wherein group (Ac) is:
• wherein:
• R7 is C1-4alkyl, C1-4alkylene(OH) or C1-4alkyleneOC1-4alkyl;
• o is 1 or 2;
• wherein group (Ad) is:
• wherein:
• X is a bond, O or CH2;
• each R8 is independently halo, C1-4alkyl, C1-4alkoxy, OC1-4haloalkyl, OC1-4alkylene(C3-6cycloalkyl), OC1-4alkylene(4-7 membered heterocycloalkyl) or OH;
• wherein said heterocycloalkyl and cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, halo, CN, OH, NR8aR8b, SO2R8c and NHSO2R8c;
• R8a is selected from H and C1-4alkyl;
• R8b is selected from H, C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, aryl and 4-7 membered heterocycloalkyl;
• R8c is selected from C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, C1-4haloalkyl, aryl and 4-7 membered heterocycloalkyl;
• each R9 is independently halo or C1-4alkyl;
• p is 0, 1 or 2;
• q is 0, 1, 2, 3 or 4;
• wherein B is:
• wherein:
• R10 is H, halo or C1-4alkyl;
• D, E and F are each independently C(R10);
• or one of D, E and F is N and the two remaining D, E and F groups are independently C(R10);
• and
• provided that the compound of formula (I) is not (E)-N-(3-fluoro-2-methylphenyl)-3-(1H-indazol-6-yl)acrylamide;
• or a pharmaceutically acceptable salt and/or solvate thereof.