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US 12,497,358 B2Granted
Inhibitor of EIF2α dephosphorylation
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsJean-Philip Lumb, Colin Crist
Life of this patent
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Abstract
The present disclosure relates to a compound of formula (I) where R1 is as defined herein. The compound of formula I is an inhibitor of the dephosphorylation of phosphorylated elF2α. The phosphorylation of elF2α affects the quiescence and self renewal properties of stem cells such as muscle stem cells. The compound of formula (I) can thus be used to expand stem cells populations and treat degenerative diseases that have a quiescence regulation affected or mediated by the phosphorylation of elF2α.
Claims19
A compound of formula (I)
- a hydrate and/or a pharmaceutical salt thereof;
- wherein R1 is a C3-C8 cycloalkyl or a tert-butyl.
Dependencies are inferred from the claim text.