Process for preparation of mesotrione and its intermediates
AssigneeRallis India Limited
InventorsA.S. Paniraj, Suresh D. Kumar, Adithya S.V.R.
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Abstract
The present disclosure provides a new and improved process for preparation of intermediate compounds and synthesis of mesotrione therefrom. The present disclosure provides an economical, efficient and eco-friendly process for preparation of mesotrione.
Claims10
A process for preparation of mesotrione of formula (I), which comprises:
- (i) oxidizing 2-nitro-4-methylsulfonyl toluene (NMST) of formula (IV) using an oxidant in presence of ruthenium oxide as a catalyst, to produce 2-nitro-4-methylsulphonyl benzoic acid (NMSBA) of formula (III);
- (ii) reacting NMSBA of formula (III) with 1,3-cyclohexanedione to produce an enol ester of formula (II);
- and
- (iii) converting the enol ester of formula (II) to mesotrione of formula (I)
A process for preparation of 2-nitro-4-methylsulphonyl benzoic acid (NMSBA) of formula (III) by oxidizing 2-nitro-4-methylsulfonyl toluene (NMST) of formula (IV) using an oxidant in presence of ruthenium oxide as a catalyst.
A process for preparation of an enol ester of formula (II) by reaction of 2-nitro-4-methylsulphonyl benzoic acid (NMSBA) of formula (III) with 1,3-cyclohexanedione
A process for preparation of an enol ester of formula (II) using 2-nitro-4-methylsulfonyl toluene (NMST) of formula (IV) as starting material, wherein the process comprises the steps of:
- (i) oxidizing 2-nitro-4-methylsulfonyl toluene (NMST) of formula (IV) using an oxidant in presence of ruthenium oxide as a catalyst, to produce 2-nitro-4-methylsulphonyl benzoic acid (NMSBA) of formula (III);
- and
- (ii) reacting NMSBA of formula (III) with 1,3-cyclohexanedione to produce the enol ester of formula (II)
Dependencies are inferred from the claim text.