Process for the purification of (R)-2-amino-3-phenylpropyl carbamate
AssigneeFlamma S.P.A.
InventorsFrancesco Chiesa, Leila Vahdati, Mario Scotti, Daniela Comi, Paolo Cremonesi, Maria Argese, Massimo Verzini, Wei He
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Abstract
The present invention relates to a process for the purification of (R)-2-amino-3-phenylpropyl carbamate in perspective of the subsequent conversion in the corresponding HCl salt (SOLRIAMFETOL). The invention further relates to the process for preparing a batch of purified solriamfetol, as well as to the purified (R)-2-amino-3-phenylpropyl carbamate or its hydrochloride salt.
Claims17
A process for purifying (R) 2-amino-3-phenylpropyl carbamate comprising the steps of:
- a) adding an aliphatic or aromatic monocarboxylic acid selected from the group consisting of trifluoroacetic acid, lauric acid, C1-C4 monoalkyl benzoic acid, C1-C4 dialkyl benzoic acid, alkoxybenzoic acid, phenylacetic acid, biphenyl-4-carboxylic acid, hydroxybenzoic acid, nitro benzoic acid and halo-benzoic acid to a solution comprising (R) 2-amino-3-phenylpropyl carbamate to form an organic salt of the (R) 2-amino-3-phenylpropyl carbamate;
- and
- b) precipitating the organic salt to obtain an isolated and purified organic salt of (R) 2-amino-3-phenylpropyl carbamate.
A process for manufacturing a hydrochloride salt of (R) 2-amino-3-phenylpropyl carbamate, comprising the steps of:
- a) adding an aliphatic or aromatic monocarboxylic acid selected from the group consisting of trifluoroacetic acid, lauric acid, C1-C4 monoalkyl benzoic acid, C1-C4 dialkyl benzoic acid, alkoxybenzoic acid, phenylacetic acid, biphenyl-4-carboxylic acid, hydroxybenzoic acid, nitro benzoic acid and halo-benzoic acid to a solution comprising (R) 2-amino-3-phenylpropyl carbamate to form an organic salt of the (R) 2-amino-3-phenylpropyl carbamate;
- b) precipitating the organic salt to obtain an isolated and purified organic salt of (R) 2-amino-3-phenylpropyl carbamate;
- and
- c) converting the isolated and purified organic salt into the hydrochloride salt of (R) 2-amino-3-phenylpropyl carbamate.
Dependencies are inferred from the claim text.